Myotubularin related protein 2 (MTMR2) is a member of the myotubularin family of phosphoinositide lipid phosphatases whose subcellular localization is regulated by a phosphorylation event on Ser 58. Our laboratory has shown that the phosphorylationmimetic mutant (S58E) targets MTMR2 to the cytoplasm, whereas the phosphorylationdeficient variant MTMR2 (S58A) targets it to Rab5 positive endosomes resulting in PI(3)P depletion. Although MTMR2 dephosphorylates PI(3)P and PI(3,5)P2, the phosphoinositide binding proteins that are regulated by MTMR2 are poorly characterized.
So yesterday, I ran to Fairways on 125th street. I had a good experience getting chicken in a paper wrapper on 72nd street, but 125th street was a bust. First of all I had to explain what I wanted in Spanish which was tricky. We’ve made a lot of advances in medicine. A doctor can put a tiny stent in your heart and stop a heart attack; we have precise chemotherapies for cancers that were once undefeatable. Yet surprisingly, the most basic elements of the body’s suffering pain, nausea, and in my case, that night of nocturnal itching remain mysterious, their mechanisms vague and still relatively undefined..
One adaptive mechanism aquatic populations use to facilitate tolerance to environmental contaminants is acclimation. Polychlorinated biphenyls (PCBs) are a globally ubiquitous class of persistent organic contaminants that have been linked to reproductive impairments in fish. They compared egg diameter, gonadosomatic index (GSI), and fecundity of fish directly caught from wild populations exposed to a range of contaminant concentrations (acute), to those collected from the same populations a year before, which were placed in a clean environment to clear their contaminants throughout that year (cleared).
Mr. Jeff Peterson, another avid cave diver, explored Florida larger springs and now has seen worrisome changes in Weeki Wachee Springs. When he hands his findings over to state water officials, he said, “They say thank you” but that is all. Lorraine Motel could be a parking lot, for all you know, today if it hadn been for D Bailey, said Clinton, who reminded the mourners that he attended the museum dedication as governor of Arkansas.He left a monument that will have to be moved, not physically but internally, he said. Can imagine if you are not of a certain age what the civil rights museum means to those of us who were young when Martin Luther King was killed in Memphis. The black garbed church choir started the service with soothing strains, Judge Bailey body lay at the front in an open, wood casket.